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Journal: International Journal of Molecular Sciences
Article Title: Hedyotis diffusa Suppresses Colitis-Associated Colorectal Cancer via Inhibition of the IL-17A-IL-17RA Axis and NF-κB Signaling
doi: 10.3390/ijms27041745
Figure Lengend Snippet: Molecular docking of FA with the IL-17A/IL-17RA complex. The overall docking model shows FA (red) binding at the interface between IL-17A (blue) and IL-17RA (green). The enlarged panel shows a close-up view of the interaction between FA and IL-17A chain B, where hydrogen bonds are indicated by yellow dashed lines.
Article Snippet: Mouse monoclonal antibody against p65 (MAB3026),
Techniques: Binding Assay
Journal: International Journal of Molecular Sciences
Article Title: Hedyotis diffusa Suppresses Colitis-Associated Colorectal Cancer via Inhibition of the IL-17A-IL-17RA Axis and NF-κB Signaling
doi: 10.3390/ijms27041745
Figure Lengend Snippet: Effects of HD and FA on NF-κB activation, IL-17A production, and granulocyte infiltration in rectal tissues of AOM/DSS-induced CRC mice. Mice were treated with HD (200 mg/kg) or FA (100 mg/kg) for 91 days. Rectal sections were stained with antibody against p65, IL-17A, or CD11b (200× magnification). Scale bar = 100 µm. Representative images are shown. Quantitative analysis of the stained area or cells (%) is displayed below the image. Data are expressed as mean ± SD (n = 8 mice per group). ### p < 0.001 vs. mock group. ** p < 0.01, *** p < 0.001 vs. CRC group.
Article Snippet: Mouse monoclonal antibody against p65 (MAB3026),
Techniques: Activation Assay, Staining